Unraveling the role of the gut microbiota in immune senescence and ageing in population-based cohorts
The aim of this sub work-package is to identify the microbial species and bacterial pathways associated with signature of immunogical ageing, cellular senescence and cardiometaboic risk in human population cohorts. To do so, we will make use several human cohorts, including LifeLines-DEEP, LifeLines-DAG3, 500FG and 300-Obese cohorts (Fig).
We have three specific objectives:
Objective 1: To identify immune senescence markers of ageing
Objective 2: To identify the effect of the gut microbiome on immune senescence
Objective 3: To identify the diet-gut microbiome-immune senescence interaction in CVD
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