1.

Metabolite Profile of Treatment-Naive Metabolic Syndrome Subjects in Relation to Cardiovascular Disease Risk.

Warmbrunn MV, Koopen AM, de Clercq NC, de Groot PF, Kootte RS, Bouter KEC, Ter Horst KW, Hartstra AV, Serlie MJ, Ackermans MT, Soeters MR, van Raalte DH, Davids M, Nieuwdorp M, Groen AK.

Metabolites. 2021 Apr 13;11(4):236. doi: 10.3390/metabo11040236.

PMID: 33924347 

2.

Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health-Pathophysiology and Therapeutic Strategies.

Aron-Wisnewsky J, Warmbrunn MV, Nieuwdorp M, Clément K.

Gastroenterology. 2021 Jan;160(2):573-599. doi: 10.1053/j.gastro.2020.10.057. Epub 2020 Nov 27.

PMID: 33253685 Review.

3.

Donor Fecal Microbiota Transplantation Alters Gut Microbiota and Metabolites in Obese Individuals With Steatohepatitis.

Witjes JJ, Smits LP, Pekmez CT, Prodan A, Meijnikman AS, Troelstra MA, Bouter KEC, Herrema H, Levin E, Holleboom AG, Winkelmeijer M, Beuers UH, van Lienden K, Aron-Wisnewky J, Mannisto V, Bergman JJ, Runge JH, Nederveen AJ, Dragsted LO, Konstanti P, Zoetendal EG, de Vos W, Verheij J, Groen AK, Nieuwdorp M.

Hepatol Commun. 2020 Oct 7;4(11):1578-1590. doi: 10.1002/hep4.1601. eCollection 2020 Nov.

PMID: 33163830  Review.

4.

Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity.

Ter Horst R, van den Munckhof ICL, Schraa K, Aguirre-Gamboa R, Jaeger M, Smeekens SP, Brand T, Lemmers H, Dijkstra H, Galesloot TE, de Graaf J, Xavier RJ, Li Y, Joosten LAB, Rutten JHW, Netea MG, Riksen NP.

Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1787-1800. doi: 10.1161/ATVBAHA.120.314508. Epub 2020 May 28.

PMID: 32460579 

5.

Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein.

Keating ST, Groh L, Thiem K, Bekkering S, Li Y, Matzaraki V, van der Heijden CDCC, van Puffelen JH, Lachmandas E, Jansen T, Oosting M, de Bree LCJ, Koeken VACM, Moorlag SJCFM, Mourits VP, van Diepen J, Strienstra R, Novakovic B, Stunnenberg HG, van Crevel R, Joosten LAB, Netea MG, Riksen NP.

J Mol Med (Berl). 2020 Jun;98(6):819-831. doi: 10.1007/s00109-020-01915-w. Epub 2020 Apr 30.

PMID: 32350546 

6.

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan.

Keating ST, Groh L, van der Heijden CDCC, Rodriguez H, Dos Santos JC, Fanucchi S, Okabe J, Kaipananickal H, van Puffelen JH, Helder L, Noz MP, Matzaraki V, Li Y, de Bree LCJ, Koeken VACM, Moorlag SJCFM, Mourits VP, Domínguez-Andrés J, Oosting M, Bulthuis EP, Koopman WJH, Mhlanga M, El-Osta A, Joosten LAB, Netea MG, Riksen NP.

Cell Rep. 2020 Apr 21;31(3):107548. doi: 10.1016/j.celrep.2020.107548.

PMID: 32320649 

7.

Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?

Bekkering S, Saner C, Riksen NP, Netea MG, Sabin MA, Saffery R, Stienstra R, Burgner DP.

Trends Endocrinol Metab. 2020 May;31(5):378-389. doi: 10.1016/j.tem.2020.01.008. Epub 2020 Feb 8.

PMID: 32305098 Review.

8.

Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo.

van der Heijden CDCC, Groh L, Keating ST, Kaffa C, Noz MP, Kersten S, van Herwaarden AE, Hoischen A, Joosten LAB, Timmers HJLM, Netea MG, Riksen NP.

Circ Res. 2020 Jul 3;127(2):269-283. doi: 10.1161/CIRCRESAHA.119.315800. Epub 2020 Apr 3.

PMID: 32241223

9.

Defining trained immunity and its role in health and disease.

Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E.

Nat Rev Immunol. 2020 Jun;20(6):375-388. doi: 10.1038/s41577-020-0285-6. Epub 2020 Mar 4.

PMID: 32132681  Review.

10.

Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification.

Kuipers F, de Boer JF, Staels B.

Cell Metab. 2020 Mar 3;31(3):445-447. doi: 10.1016/j.cmet.2020.02.006.

PMID: 32130878

11.

Gut microbiota: a promising target against cardiometabolic diseases.

Warmbrunn MV, Herrema H, Aron-Wisnewsky J, Soeters MR, Van Raalte DH, Nieuwdorp M.

Expert Rev Endocrinol Metab. 2020 Jan;15(1):13-27. doi: 10.1080/17446651.2020.1720511.

PMID: 32066294 Review.

12.

Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?

Aron-Wisnewsky J, Warmbrunn MV, Nieuwdorp M, Clément K.

Gastroenterology. 2020 May;158(7):1881-1898. doi: 10.1053/j.gastro.2020.01.049. Epub 2020 Feb 8.

PMID: 32044317 Review.

13.

Human Postprandial Nutrient Metabolism and Low-Grade Inflammation: A Narrative Review.

Meessen ECE, Warmbrunn MV, Nieuwdorp M, Soeters MR.

Nutrients. 2019 Dec 7;11(12):3000. doi: 10.3390/nu11123000.

PMID: 31817857  Review.

14.

Sixteen-Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State.

Noz MP, Hartman YAW, Hopman MTE, Willems PHGM, Tack CJ, Joosten LAB, Netea MG, Thijssen DHJ, Riksen NP.

J Am Heart Assoc. 2019 Nov 5;8(21):e013764. doi: 10.1161/JAHA.119.013764. Epub 2019 Oct 18.

PMID: 31623506 

15.

Systems genetics approach reveals cross-talk between bile acids and intestinal microbes.

Fu J, Kuipers F.

PLoS Genet. 2019 Aug 29;15(8):e1008307. doi: 10.1371/journal.pgen.1008307. eCollection 2019 Aug.

PMID: 31465439

16.

Trained immunity and atherosclerotic cardiovascular disease.

Riksen NP.

Curr Opin Lipidol. 2019 Oct;30(5):395-400. doi: 10.1097/MOL.0000000000000628.

PMID: 31335332 Review.

17.

Aldosterone induces trained immunity: the role of fatty acid synthesis.

van der Heijden CDCC, Keating ST, Groh L, Joosten LAB, Netea MG, Riksen NP.

Cardiovasc Res. 2020 Feb 1;116(2):317-328. doi: 10.1093/cvr/cvz137.

PMID: 31119285